A SECRET WEAPON FOR BTD

Small concentrations of S1P are chemotactic for osteoclast precursors, although significant concentrations inhibit their movement 79. This suggests that these precursors, which Categorical the two S1PR1 and S1PR2, are stored inside the vicinity from the bone via the S1P gradient: S1PR2 prevents S1PR1-induced migration of those bone-resorbing cells